1 25 Vs 25 Vitamin D
Vitamin d plays an integral role in bone health specifically in calcium and phosphorus homeostasis vitamin d deficiency and insufficiency defined as serum 25 hydroxyvitamin d 25 oh d levels 20 and 21 to 29 ng ml respectively is a major health concern that extends beyond skeletal ailments because there is a vitamin d receptor in most every tissue in the body people of any age or.
1 25 vs 25 vitamin d. The major circulating form of vitamin d is 25 hydroxyvitamin d 25 oh d although it is not the most active metabolite the concentrations of total 25 hydroxyvitamin d in the serum are currently routinely used in clinical practice to assess vitamin d status. In brief while 1 25 dihydroxyvitamin d is the most potent vitamin d metabolite 25 oh vitamin d levels more accurately reflect vitamin d status since it is not influenced by pth and other hormones. Vitamin d 1 25 dihydroxy this test measures the bioactive form of vitamin d. In the circulation vitamin d like other steroid hormones is bound tightly to a.
A high level of 25 hydroxyvitamin d usually reflects excess supplementation from vitamin pills or other nutritional supplements. Because 1 25 dihydroxyvitamin d is the active form of vitamin d many practitioners think that measuring 1 25 dihydroxyvitamin d is an accurate means to estimate vitamin d stores and test for. Indeed both bind to the vitamin d receptor and produce biological effects. The 25 hydroxyvitamin d test is the recommended test for those.
It is used in the differential diagnosis of hypocalcemia and to monitor patients with renal osteodystrophy or chronic renal failure. It is not appropriate to bill medicare for services that are not covered as described by this entire lcd as if they are covered. In clinical use the differences are unlikely to have major importance. 1649 3 component test codes cannot be used to order tests.
However the terminology of 1 25 dihydroxyvitamin d or 1 25 oh 2 d is often used to refer to both types of active forms of vitamin d. In unique cases such as renal disease 1 25 dihydroxyvitamin d levels may be used to better determine vitamin d status. This test is not suitable for diagnosis of vitamin d deficiency and monitoring supplementation in most patients. In the presence of renal disease or hypercalcemia testing of 1 25 dihydroxy vitamin d dhvd might be needed to adequately assess vitamin d status.
A low level of 1 25 dihydroxyvitamin d can be seen in kidney disease and is one of the earliest changes to occur in persons with early kidney failure. Vitamin d 25 hydroxy and vitamin d 1 25 dihydroxy assays for vitamins and metabolic function coverage indications limitations and or medical necessity notice. For a complete test mix please click the sidebar link to access the interface map. Vitamin d is a generic designation for a group of fat soluble structurally similar sterols which act as hormones.